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Cell Metab. 2008 Jan;7(1):1-2. doi: 10.1016/j.cmet.2007.12.006.

Taranabant cuts the fat: new hope for cannabinoid-based obesity therapies?

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1
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK. t.c.kirkham@liverpool.ac.uk

Abstract

Endocannabinoid/cannabinoid receptor signaling acts centrally and peripherally to govern appetite and energy balance. While system stimulation promotes eating and energy storage, receptor blockade can reduce food intake and facilitate weight loss. In this issue of Cell Metabolism, Addy et al. (2008) test the therapeutic antiobesity potential of taranabant, a cannabinoid 1 receptor inverse agonist.

PMID:
18177717
DOI:
10.1016/j.cmet.2007.12.006
[Indexed for MEDLINE]
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