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J Biomater Sci Polym Ed. 2008;19(1):47-59. doi: 10.1163/156856208783227640.

Ionically cross-linked carrageenan-alginate hydrogel beads.

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Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran.


Hydrogel beads based on the carbohydrate biopolymers kappa-carrageenan and sodium alginate were newly prepared. Both classical and experimental design (Taguchi) methods were used to obtain the optimum conditions for the full-polysaccharide hydrogel preparation. The carrageenan-alginate (Caralgi) beads exhibited a surface morphology smoother than that of the one-polysaccharide network beads. Infrared spectroscopy and DSC/TGA thermal methods were used to study the chemical structure and thermal properties of the beads. The carrageenan parts appreciably enhanced thermostability of the networks. The fully carbohydrate-based hydrogel beads are expected to be biologically compatible and degradable. They are being considered as new carriers for drug loading and controlled delivery systems.

[Indexed for MEDLINE]

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