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Curr Opin Drug Discov Devel. 2008 Jan;11(1):80-5.

In silico methods for early toxicity assessment.

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GenKyoTex SA, 14 Chemin des Aulx, 1228 Plan Les Ouates, Geneva, Switzerland.


The number of new drugs that reach the market is declining every year, and, in recent years, several drugs already on the market have been withdrawn because of safety concerns. In response to this, the pharmaceutical industry is poised to take advantage of innovative methods that will increase the efficiency of its research and development. An in silico approach to predicting safety issues could provide meaningful information early on in the drug discovery process, and representing a relatively inexpensive alternative to current methods. Recent advances in the field of in silico toxicology are reviewed herein, along with a discussion of the reasons behind this increased attention.

[Indexed for MEDLINE]

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