Send to

Choose Destination
See comment in PubMed Commons below
Heart Fail Rev. 2008 Sep;13(3):311-9. doi: 10.1007/s10741-007-9077-3. Epub 2008 Jan 3.

Aminopeptidase A inhibitors as centrally acting antihypertensive agents.

Author information

U 691, Inserm, 11, Place Marcelin Berthelot, Paris Cedex 05, France.


Among the main bioactive peptides of the brain renin-angiotensin system, angiotensin (Ang) II and AngIII exhibit the same affinity for the type 1 and type 2 Ang receptors. Both peptides, injected intracerebroventricularly, cause similar increase in blood pressure (BP). Because AngII is converted in vivo to AngIII, the identity of the true effector is unknown. This review summarized recent insights into the predominant role of brain AngIII in the central control of BP underlining the fact that brain aminopeptidase A (APA), the enzyme forming central AngIII, could constitute a putative central therapeutic target for the treatment of hypertension. This led to the development of potent, systematically active APA inhibitors, such as RB150, as a prototype of a new class of centrally acting antihypertensive agents for the treatment of certain forms of hypertension.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center