Format

Send to

Choose Destination
Acta Neuropathol. 2008 Mar;115(3):275-87. doi: 10.1007/s00401-007-0320-8. Epub 2008 Jan 4.

Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach.

Author information

1
Department of Neuropathology, University Medical Centre Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany. tanjakuhlmann@gmx.de

Abstract

Multiple sclerosis is the most frequent demyelinating disease in adults. It is characterized by demyelination, inflammation, gliosis and a variable loss of axons. Clinically and histologically, it shares features with other demyelinating and/or inflammatory CNS diseases. Diagnosis of an inflammatory demyelinating disease can be challenging, especially in small biopsy specimens. Here, we summarize the histological hallmarks and most important neuropathological differential diagnoses of early MS, and provide practical guidelines for the diagnosis of inflammatory demyelinating diseases.

PMID:
18175128
PMCID:
PMC2668559
DOI:
10.1007/s00401-007-0320-8
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center