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Org Biomol Chem. 2008 Jan 21;6(2):385-90. doi: 10.1039/b716380k. Epub 2007 Dec 7.

Mycothiol disulfide reductase: solid phase synthesis and evaluation of alternative substrate analogues.

Author information

1
School of Chemistry and Chemical Engineering, David Keir Building, Stranmillis Road, Queen's University Belfast, Belfast, United Kingdom BT9 5AG.

Abstract

A solid phase synthesis of des-myo-inositol mycothiol disulfide and its alpha-configured methyl- and benzyl-glycoside derivatives has been developed. Kinetic characterisation of these compounds has demonstrated their viability as alternative substrates for use in mycothiol disulfide reductase enzyme assays.

PMID:
18175009
DOI:
10.1039/b716380k
[Indexed for MEDLINE]

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