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Br J Psychiatry. 2008 Jan;192(1):25-31. doi: 10.1192/bjp.bp.107.036558.

Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control.

Author information

1
Child and Adolescent Psychiatry (PO 46), Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK. k.rubia@iop.kcl.ac.uk

Abstract

BACKGROUND:

Obsessive-compulsive disorder (OCD) may be related to a dysfunction in frontostriatal pathways mediating inhibitory control. However, no functional magnetic resonance imaging (fMRI) study has tested this in children.

AIMS:

To test whether adolescents with OCD in partial remission would show abnormal frontostriatal brain activation during tasks of inhibition.

METHOD:

Event-related fMRI was used to compare brain activation in 10 adolescent boys with OCD with that of 9 matched controls during three different tasks of inhibitory control.

RESULTS:

During a 'stop' task, participants with OCD showed reduced activation in right orbitofrontal cortex, thalamus and basal ganglia; inhibition failure elicited mesial frontal underactivation. Task switching and interference inhibition were associated with attenuated activation in frontal, temporoparietal and cerebellar regions.

CONCLUSIONS:

These preliminary findings support the hypothesis that paediatric OCD is characterised by a dysregulation of frontostriatothalamic brain regions necessary for motor inhibition, and also demonstrate dysfunction of temporoparietal and frontocerebellar attention networks during more cognitive forms of inhibition.

PMID:
18174505
DOI:
10.1192/bjp.bp.107.036558
[Indexed for MEDLINE]

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