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J Clin Invest. 2008 Jan;118(1):6-14. doi: 10.1172/JCI32483.

Antipsychotics in the treatment of autism.

Author information

1
Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. dposey@iupui.edu

Abstract

Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.

PMID:
18172517
PMCID:
PMC2171144
DOI:
10.1172/JCI32483
[Indexed for MEDLINE]
Free PMC Article

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