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Ir Med J. 1991 Dec-1992 Jan;84(4):116-8.

Carrier detection for X-linked agammaglobulinaemia (Bruton type) in an Irish family using linked DNA probes.

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I. Mothercare Department of Paediatric Genetics, Institute of Child Health, London.


Being an X-linked condition, the sisters of men with X-linked agammaglobulinaemia have a 50% risk of being carriers of the disease gene (provided the disease has not developed as a results of a new mutation). We demonstrate how this risk can be modified very significantly by DNA analysis using linked DNA probes. The value of such tests for genetic purposes is discussed.

[Indexed for MEDLINE]

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