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Cancer Cell. 2008 Jan;13(1):48-57. doi: 10.1016/j.ccr.2007.12.008.

MicroRNA signature predicts survival and relapse in lung cancer.

Author information

1
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan 100, Republic of China.

Abstract

We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.

PMID:
18167339
DOI:
10.1016/j.ccr.2007.12.008
[Indexed for MEDLINE]
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