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Pak J Pharm Sci. 2008 Jan;21(1):7-11.

Subchronic treatment with mercuric chloride suppresses immune response, elicits behavioral deficits and increases brain serotonin and dopamine metabolism in rats.

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1
Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Unit, University of Karachi, Karachi. hajra20052005@yahoo.com

Abstract

In view of the neurotoxic effects of mercuric chloride the following study was designed to explore its effects on brain serotonin and dopamine metabolism. Mercuric chloride injected at a dose of 1 mg/ml/kg increased locomotor activity, decreased latency to move, corner sittings and food intake. A decrease of 33% of immune response was observed in mercuric chloride treated rats as evident from anti nuclear antibody (ANA) positive test. Neurochemical analysis revealed that mercuric chloride administration increased brain tryptophan concentrations 5-Hydroxyindoleacetic acid (5-HIAA) and dihydroxyphenyl acetic acid, while 5-Hydroxytryptamine (5-HT) and Dopamine (DA) were decreased. The results also showed an increase in brain 5-HT and DA turnover rate in mercuric chloride injected rats. These increases in 5-HT and DA metabolism suggest that mercuric chloride may tend to contribute to anorexia and hyperactivity induced in drug administered rats.

PMID:
18166511
[Indexed for MEDLINE]
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