Format

Send to

Choose Destination
Fertil Steril. 2008 Nov;90(5):1826-33. doi: 10.1016/j.fertnstert.2007.09.020. Epub 2007 Dec 31.

Is there a role for soy isoflavones in the therapeutic approach to polycystic ovary syndrome? Results from a pilot study.

Author information

1
Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, Rome, Italy.

Abstract

OBJECTIVE:

To evaluate the effect of the soy isoflavone genistein on the metabolic and hormonal disturbances of polycystic ovary syndrome (PCOS), we studied a group of obese, hyperinsulinemic, and dyslipidemic women presenting this syndrome during 6 months of phytoestrogen administration.

DESIGN:

Pilot prospective study.

SETTING:

Operative division of endocrinological gynecology in a university hospital.

PATIENT(S):

Twelve Caucasian obese, hyperinsulinemic, and dyslipidemic women with PCOS.

INTERVENTION(S):

Patients received 36 mg/d of genistein for 6 months. Ultrasonographic pelvic exams, hormonal and lipid features, oral glucose tolerance test, and euglycemic hyperinsulinemic clamp were performed at baseline and after 3 and 6 months of treatment.

MAIN OUTCOME MEASURE(S):

Basal hormonal assays, lipid profile, and glycoinsulinemic assessment.

RESULT(S):

Phytoestrogens supplementation significantly improved total cholesterol levels, reducing low-density lipoprotein (LDL) cholesterol and resulting in a significant decrease in the LDL-high-density lipoprotein ratio (LDL-HDL). Triglycerides showed a trend toward decrease, whereas no changes were detected in very low-density lipoprotein cholesterol plasma levels. Genistein treatment did not significantly affect anthropometric features, the hormonal milieu, and menstrual cyclicity. No significant changes occurred in glycoinsulinemic metabolism.

CONCLUSION(S):

The possible advantages derived from the therapeutic use of phytoestrogens in PCOS are limited to improvement of the lipidic assessment.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center