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J Neuroimmunol. 2008 Feb;194(1-2):54-61. doi: 10.1016/j.jneuroim.2007.11.006. Epub 2007 Dec 31.

Production and functions of IL-17 in microglia.

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1
Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusaku, Nagoya 464-8601, Japan.

Abstract

Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1beta. Because microglia produce IL-1beta and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.

PMID:
18164424
DOI:
10.1016/j.jneuroim.2007.11.006
[Indexed for MEDLINE]
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