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Cell Mol Immunol. 2007 Dec;4(6):407-18.

The interferon signaling network and transcription factor C/EBP-beta.

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Department of Microbiology & Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, 660 W. Redwood Street, Baltimore, MD 21201, USA.


Cytokines like interferons (IFNs) play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-beta in mediating these responses.

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