Format

Send to

Choose Destination
Arch Pediatr. 2008 Jan;15(1):33-6. Epub 2007 Dec 26.

[Congenital transient leukemia: a case report].

[Article in French]

Author information

1
Service d'hématologie-oncologie pédiatrique, CHU Nord, place Victor-Pauchet, 80054 Amiens cedex, France. lithiaote.valerie@chu-amiens.fr

Abstract

Neonates with Down's syndrome have an increased risk for congenital leukaemia, particularly acute megakaryoblastic leukaemia (FAB, M7) which most often resolves spontaneously and is called transient leukaemia. It can be observed in non-constitutional trisomy 21 infants then presenting trisomy 21 on blasts cells.

OBSERVATION:

We report a transient leukaemia with an isolated pericardial effusion in a phenotypically normal neonate. Trisomy 21 was found on blasts cells. Complete remission remains after 32 months.

DISCUSSION:

Congenital leukaemias, with trisomy 21 on blasts cells have a good prognosis that justifies observation before using chemotherapy.

PMID:
18162385
DOI:
10.1016/j.arcped.2007.08.023
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center