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Aliment Pharmacol Ther. 2008 Mar 15;27(6):514-9. Epub 2007 Dec 21.

The association between coeliac disease and cardiovascular disease.

Author information

1
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK.

Abstract

BACKGROUND:

Coeliac disease is more prevalent than was previously thought. The association between coeliac disease and cardiovascular outcome is not clear.

AIM:

To investigate whether coeliac disease patients have an increased risk of cardiovascular events.

METHODS:

A community-based cohort study using a record-linkage database. Three hundred and sixty-seven coeliac patients identified by a positive antiendomysial antibody test or a diagnosis with small bowel biopsy, and 5537 subjects who were tested and had a negative coeliac immunology, were included in the study.

RESULTS:

The crude rates of cardiovascular events were 9.5 per 1000 person-years (95% CI: 4.4-14.6) in the coeliac cohort and 8.9 per 1000 person-years (95% CI: 7.6-10.3) in the antiendomysial antibody-negative cohort. Compared with the antiendomysial antibody-negative cohort, the adjusted relative risk of cardiovascular events for coeliac cohort was 1.9 (95% CI: 1.00-3.60). When we excluded patients who had previous hospitalization for cardiovascular disease, the adjusted relative risk was 2.5 (95% CI: 1.22-5.01). The use of any cardiovascular drugs prior to and after entry to the study were 36% and 29% for the coeliac cohort (P = 0.05), and 34% and 26% for the antiendomysial antibody-negative cohort (P < 0.01).

CONCLUSION:

Our findings suggest that coeliac disease seems to be associated with an increased risk of cardiovascular outcome.

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