Send to

Choose Destination
Am J Drug Alcohol Abuse. 2008;34(1):109-21.

Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence.

Author information

Department of Psychiatry, Harvard Medical School and Center for Sleep and Cognition, Beth Israel-Deaconess Medical Center, Boston, Massachusetts 02115, USA.


Seventeen non-treatment seeking cocaine-dependent individuals participated in three-week longitudinal inpatient studies of cognitive changes during drug use and abstinence. Protocols included three days drug-free baseline, three days cocaine self-administration, and two weeks complete abstinence. A repeatable cognitive battery showed attention and delayed verbal recognition memory but not working memory to be impaired in cocaine users compared to age- and sex-matched normative values. Attention was significantly poorer during the first and second week of abstinence compared to days on which cocaine was used suggesting that certain cocaine-induced impairments may be acutely normalized by cocaine use, but resurface during abstinence.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center