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Bioorg Med Chem Lett. 2008 Feb 1;18(3):1058-62. Epub 2007 Dec 10.

Targeting ACE and ECE with dual acting inhibitors.

Author information

1
Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-Ville, Montréal, QB, Canada. stephen.hanessian@umontreal.ca

Abstract

A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.

PMID:
18160283
DOI:
10.1016/j.bmcl.2007.12.013
[Indexed for MEDLINE]

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