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Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):485-98. Epub 2007 Nov 7.

Calcitonin-derived peptide carriers: mechanisms and application.

Author information

1
Institute of Biochemistry, Faculty of Bioscience, Pharmacy and Psychology, Leipzig University, BrĂ¼derstr. 34, D-04103 Leipzig, Germany.

Abstract

Among the family of the so-called cell-penetrating peptides (CPP) sequences derived from the native peptide hormone human calcitonin (hCT) have recently proven to translocate different bioactive molecules across cellular membranes. Herein, we give an extensive summary of the development of hCT-derived carrier peptides, beginning with the therapeutic nasal administration of full-length hCT. Hence, N-terminally truncated hCT fragments were investigated and subsequently optimised to extend their field of application. The latest generation of hCT-derived carrier peptides are highly effective, branched peptides. The current state of the art is reviewed concerning the structural requirements, mechanistic assumptions and metabolic features of these peptides as well as experiments proving their excellent carrier potential.

PMID:
18160173
DOI:
10.1016/j.addr.2007.09.008
[Indexed for MEDLINE]
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