Send to

Choose Destination
J Autism Dev Disord. 2008 Sep;38(8):1581-90. Epub 2007 Dec 22.

Brief report: methods for acquiring structural MRI data in very young children with autism without the use of sedation.

Author information

M.I.N.D. Institute and Department of Psychiatry and Behavioral Sciences, University of California at Davis, 2805 50th Street, Sacramento, CA, 95817, USA.


We describe a protocol with which we achieved a 93% success rate in acquiring high quality MRI scans without the use of sedation in 2.5-4.5 year old children with autism, developmental delays, and typical development. Our main strategy was to conduct MRIs during natural nocturnal sleep in the evenings after the child's normal bedtime. Alternatively, with some older and higher functioning children, the MRI was conducted while the child was awake and watching a video. Both strategies relied heavily on the creation of a child and family friendly MRI environment and the involvement of parents as collaborators in the project. Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center