Format

Send to

Choose Destination
See comment in PubMed Commons below
Eye (Lond). 2007 Dec;21 Suppl 1:S11-4.

The neurobiology of cell death in glaucoma.

Author information

1
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792, USA.

Abstract

Glaucoma is an optic neuropathy in which the optic nerve axons are damaged, resulting in death of retinal ganglion cells (RGCs). The primary region of damage is thought to be the optic nerve head (ONH), with the lateral geniculate nucleus (LGN) and optic radiations to the visual cortex being secondarily affected. Neurotrophin deprivation resulting from optic nerve injury is thought to cause RGCs to die by apoptosis by inhibition of cell survival pathways. However, disruption of retrograde axonal transport is not the only mechanism associated with optic nerve damage and RGC death, and thus, an additional mechanism of injury is likely to be involved in glaucomatous optic neuropathy.

PMID:
18157171
DOI:
10.1038/sj.eye.6702880
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center