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Fertil Steril. 2008 Nov;90(5):1656-61. Epub 2007 Dec 21.

Menstrual cycle length is an age-independent marker of female fertility: results from 6271 treatment cycles of in vitro fertilization.

Author information

1
Department of Obstetrics and Gynaecology, Eskilstuna, Sweden. thomasbrodin@telia.com

Abstract

OBJECTIVE:

To investigate whether menstrual cycle length correlates with success rates at IVF/intracytoplasmic sperm injection (ICSI) and could be used as a marker of ovarian reserve.

DESIGN:

Prospective observational study.

SETTING:

Private infertility centre.

PATIENT(S):

A total of 6271 IVF/ICSI treatment cycles.

INTERVENTION(S):

Self-reported mean number of menstrual days during the last year was recorded before initiation of IVF/ICSI treatment.

MAIN OUTCOME MEASURE(S):

Relations between menstrual cycle length and pregnancy and delivery rates.

RESULT(S):

Increasing age was associated with a subtle shortening of mean menstrual cycle length. Menstrual cycle length correlated linearly with pregnancy and delivery rates, even after age adjustment. The chance of delivery after IVF/ICSI was almost doubled for women with a menstrual cycle length >34 days compared with women with a menstrual cycle length <26 days. Menstrual cycle length was also significantly associated with ovarian response to FSH/hMG stimulation and embryo quality.

CONCLUSION(S):

Mean menstrual cycle length is highly related to success rates in assisted reproduction, independently of age. A precise menstrual cycle history could be used as a simple marker of ovarian reserve.

[Indexed for MEDLINE]

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