Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2008 Jan 23;582(2):305-9. Epub 2007 Dec 26.

A family of eukaryotic lysophospholipid acyltransferases with broad specificity.

Author information

  • 1Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden. ulf.stahl@vbsg.slu.se

Abstract

The budding yeast ALE1 gene encodes a lysophospholipid acyltransferase (LPLAT) with broad specificity. We show that yeast LPLAT (ScLPLAT) belongs to a distinct protein family that includes human MBOAT1, MBOAT2, MBOAT4, and several closely related proteins from other eukaryotes. We further show that two plant proteins within this family, the Arabidopsis proteins AtLPLAT1 and AtLPLAT2, possess lysophospholipid acyltransferase activities similar to ScLPLAT. We propose that other members of this protein family, which we refer to as the LPLAT family, also are likely to possess LPLAT activity. Finally, we show that ScLPLAT differs from the specific lysophosphatidic acid acyltransferase that is encoded by SLC1 in that it cannot efficiently use lysophosphatidic acid produced by acylation of glycerol-3-phosphate in vitro.

PMID:
18154737
DOI:
10.1016/j.febslet.2007.12.020
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center