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J Basic Microbiol. 1991;31(5):337-45.

Nucleotide sequence of a variant protein A of Staphylococcus aureus suggests molecular heterogeneity among strains.

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Ludwig Institute for Cancer Research, São Paulo Branch, Brasil.


Protein A is a cell wall linked protein of Staphylococcus aureus that binds mammalian IgG. Although protein A displays high size heterogeneity among strains, cloning and sequencing of its gene from two strains had not shown a large difference in size. Here we report a third protein A gene sequence that shows a size variation relative to these two, due to deletions on both one IgG binding domain and a cell wall binding domain (region X). By analysis of the three sequences we were able to delineate a hypothetic model for region X domain evolution and discussed the origin of genetic variability within and without strains.

[Indexed for MEDLINE]

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