Calmodulin was detected in the cytoskeleton fraction of the olfactory tissue of vertebrates (pig, rat), identified by electrophoretical mobility and by immunoblotting. The approximate content of calmodulin in the cytoskeleton fraction was about 23% relative to all the proteins revealed on the electrophoregram. Another protein was detected in the same experiments having the same molecular weight as calmodulin and revealing immunospecific properties.