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J Craniofac Genet Dev Biol. 1991 Oct-Dec;11(4):223-8.

Role of the early epithelium in the patterning of the teeth and Meckel's cartilage.

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Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06032.


Embryonic epithelium from the mandibular branchial arch organizes the dentition and the deposition of Meckel's cartilage. During 9-11 days of gestation mandibular arch epithelium can induce teeth in nondental ectomesenchyme in both mice and birds. In addition, the deposition of Meckel's cartilage as a rod of cartilage in the middle of the first branchial arch is under the control of the epithelium. The epithelium inhibits chondrogenesis; if it is removed, large amorphous masses of cartilage are found instead of the narrow rod typical of Meckel's cartilage.

[Indexed for MEDLINE]

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