[Fibrinolytic treatment with urokinase and streptokinase for recurrent thrombosis in two valve prostheses for the aortic and mitral valves during pregnancy]

J Gynecol Obstet Biol Reprod (Paris). 1991;20(8):1093-6.
[Article in French]

Abstract

The authors report a case of a patient who had two episodes of valvular thrombosis successfully treated with fibrinolysis using urokinase and streptokinase. They emphasise how efficient these treatments are in spite of the gravity of the initial picture and also point out the dangers and difficulties that can occur because of the risk of haemorrhage in pregnancy, and particularly during delivery and post-partum. They show once more that the treatment is harmless for the fetus. They conclude that using fibrinolytic treatment should be considered first when there is great danger to the patient, and the advantages and disadvantages of thrombolysis should be weighed up.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adult
  • Aortic Valve Insufficiency / complications
  • Aortic Valve Insufficiency / surgery
  • Clinical Trials as Topic
  • Drug Monitoring
  • Female
  • Heart Valve Prosthesis*
  • Humans
  • Mitral Valve Stenosis / complications
  • Mitral Valve Stenosis / surgery
  • Postoperative Complications / blood
  • Postoperative Complications / drug therapy*
  • Postoperative Complications / etiology
  • Pregnancy
  • Pregnancy Complications, Hematologic / blood
  • Pregnancy Complications, Hematologic / drug therapy*
  • Pregnancy Complications, Hematologic / etiology
  • Recurrence
  • Streptokinase / administration & dosage
  • Streptokinase / pharmacology
  • Streptokinase / therapeutic use*
  • Thrombosis / blood
  • Thrombosis / drug therapy*
  • Thrombosis / etiology
  • Urokinase-Type Plasminogen Activator / administration & dosage
  • Urokinase-Type Plasminogen Activator / pharmacology
  • Urokinase-Type Plasminogen Activator / therapeutic use*

Substances

  • Streptokinase
  • Urokinase-Type Plasminogen Activator