Thus, basing on the data obtained it was stated that the destructive pancreatitis is always accompanied by intoxication. A certain weakening of the immune mechanisms took place, mainly of its T-cellular chain. Detox methods of treatment had different effects on the organism. The most effective among them happened to be plasmapheresis and spleen-xeno as they significantly decrease hyperfermentation and toxemia. The application of hemosorption and ultra-violet irradiation of blood had favourable immunocorrective effect at the early stage. It should be noted that the application of spleen-xeno was normalizing the immune mechanisms at the later stage of experimental acute pancreatitis.