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Obstet Gynecol. 1991 Oct;78(4):656-9.

Controlled ovarian hyperstimulation as a risk factor for ectopic pregnancy.

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  • 1Department of Gynecology and Obstetrics, Hôpital A. Béclère, Clamart, France.


As part of a case-control study of ectopic pregnancy, we evaluated the potential etiologic role of controlled ovarian hyperstimulation in a population with no previous history of ectopic pregnancy. Ovulation induction alone was associated with an increased risk of ectopic pregnancy (adjusted odds ratio = 3.98; 95% confidence interval 1.10-14.30). In contrast, ovulation induction for in vitro fertilization did not increase the risk further (adjusted odds ratio = 2.45; 95% confidence interval 0.54-11.13). These results suggest that hormonal factors may be involved in the development of ectopic pregnancy.

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