An evaluation of intrastromal injection of antifungal agents

J Ocul Pharmacol. 1991 Winter;7(4):325-8. doi: 10.1089/jop.1991.7.325.

Abstract

The effect of the intrastromal injection of a mixture of amphotericin B, miconazole, natamycin, and nystatin and the component agents alone was studied in Dutch-belted rabbits by standard bioassay. Twenty-four hours following injection, the inhibiting effect of the mixture was equivalent to that of nystatin alone. All other agents exhibited inferior activity. The intrastromal injection of this mixture appears to offer no therapeutic advantage.

MeSH terms

  • Amphotericin B / pharmacokinetics
  • Animals
  • Antifungal Agents / pharmacokinetics*
  • Aqueous Humor / metabolism
  • Candida albicans / drug effects
  • Corneal Stroma / metabolism*
  • Drug Therapy, Combination / pharmacokinetics
  • Injections
  • Miconazole / pharmacokinetics
  • Natamycin / pharmacokinetics
  • Nystatin / pharmacokinetics
  • Rabbits

Substances

  • Antifungal Agents
  • Nystatin
  • Miconazole
  • Amphotericin B
  • Natamycin