Format

Send to

Choose Destination
Drug Dev Ind Pharm. 2007 Dec;33(12):1350-61.

Raft-forming agents: antireflux formulations.

Author information

1
Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, India. chhandakapadia@rediffmail.com

Abstract

Gastroesophageal reflux disease (GERD) is caused by excessive reflux of gastric content and duodenal bile into the esophagus, and impaired clearance of refluxate from the esophagus. In this perspective, raft-forming antireflux formulations offer better alternatives to the conventional therapies for treatment of uncomplicated GERD. In addition to the alginate-based systems, various natural polysaccharides have generated interest as raft-forming agents because of their bioadhesive/mucoprotective nature. Inclination of current therapy is towards natural products for healing of the disease, which also underlines the market potential of this class, demanding for thorough investigation and development of evaluation methods with better in vitro-in vivo correlation.

PMID:
18097809
DOI:
10.1080/03639040701385691
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center