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Proc Am Thorac Soc. 2008 Jan 1;5(1):47-57.

Regulation of heterotrimeric G protein signaling in airway smooth muscle.

Author information

1
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. rpenn@wfubmc.edu

Abstract

Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.

PMID:
18094084
PMCID:
PMC2645302
DOI:
10.1513/pats.200705-054VS
[Indexed for MEDLINE]
Free PMC Article

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