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Boll Chim Farm. 1991 Dec;130(11):431-8.

Phytosome: new cosmetic delivery system.

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Indena SpA, Milan, Italy.


Modern cosmetology is increasingly alternating with dermatology as a discipline concerns the treatment of non pathological skin. One of the main problems is the transcutaneous absorption of active principles. The modern cosmetologist, is confronted with the need of findings means to facilitate the passage across skin of active products. Liposomes are artificial phospholipid membranes that can facility the passage of active principles across the stratum conneum. After the fortuitous observation that phospholipids exhibit a marked affinity for some classes of flavonoids, we have developed a new series of compounds denominate "phytosome", which we have obtained by complexation with very polar botanical derivatives. From the chemical viewpoint the PHYTOSOME are complexes between a pure phospholipid and a pure active principles. The authors realize at industrial level a certain number of that complexes. In the work are presents the chemico physical properties of complexes with catechin, quercetin, escin and glycyrrhetinic acid; some pharmacological data obtained are presented.

[Indexed for MEDLINE]

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