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Org Lett. 2008 Jan 17;10(2):289-92. Epub 2007 Dec 20.

(BDP)CuH: a "hot" Stryker's reagent for use in achiral conjugate reductions.

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1
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

Abstract

A ligand-modified, economical version of Stryker's reagent (SR) has been developed based on a bidentate, achiral bis-phosphine. Generated in situ, "(BDP)CuH" smoothly effects conjugate reductions of a variety of unsaturated substrates, including those that are normally unreactive toward SR. Substrate-to-ligand ratios typically on the order of 1000-10000:1 can be used leading to products in high yields.

PMID:
18092793
DOI:
10.1021/ol702689v
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