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Ann Rech Vet. 1991;22(4):387-94.

[Pharmacokinetics of colistin sulfate administered by intravenous and intramuscular routes in the calf].

[Article in French]

Author information

1
Centre national d'études vétérinaires et alimentaires, laboratoire des médicaments vétérinaires, Fougères, France.

Abstract

Pharmacokinetic characteristics of an extemporaneous form of colistin sulfate in young calves were studied for a dosage of 25,000 IU.kg-1. The intravenous route (IV) is characterized by a 3-compartment model whose main parameters are: volume of distribution (1.02 l.kg), body clearance (0.15 l.h-1 kg-1) and mean residence time (3.87 h). By intramuscular route (IM), a mean serum peak of 37 IU.ml-1 was reached at a mean time of 0.5 h. The mean half-time of terminal phase (6.47 h) does not differ significantly from that of the intramuscular route (4.52 h). Absolute bioavailability calculated based on 4 calves was 109 +/- 28%. Repeated IM administrations seem to be adapted to maintain a bactericidal activity and to reduce risks of toxicity and neurological disorders (25,000 IU.kg-1) every 12 h over 3d.

PMID:
1809216
[Indexed for MEDLINE]

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