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J Ren Nutr. 2008 Jan;18(1):12-7.

Is homocysteine toxic in uremia?

Author information

1
First Division of Nephrology, Department of Pediatrics, and Cardiovascular Research Center, School of Medicine, Second University of Naples, Naples, Italy. alessandra.perna@unina2.it

Abstract

High levels of homocysteine have been implicated as a cardiovascular risk factor in the general population and in patients with chronic renal failure, and particularly patients on hemodialysis. To classify a risk factor as causally related to a certain disease, both strong epidemiologic data and sound basic-science studies establishing a mechanism are needed. Among the latter, the hypomethylation of proteins and DNA, and protein homocysteinylation, have been investigated in uremia, providing for an array of toxic effects in this disease.

PMID:
18089438
DOI:
10.1053/j.jrn.2007.10.005
[Indexed for MEDLINE]

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