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Med Microbiol Immunol. 2008 Jun;197(2):261-7. Epub 2007 Dec 18.

The functions of herpesvirus-encoded microRNAs.

Author information

1
Vaccine and Gene Therapy Institute, Oregon Health Sciences University, 505 NW 185th Ave, Portland, OR 97006, USA. greyf@ohsu.edu

Abstract

Bioinformatic and direct cloning approaches have led to the identification of over 100 novel miRNAs expressed in DNA viruses, although the function of the majority of these small regulatory RNA molecules is unclear. Recently, a number of reports have now identified potential targets of viral miRNAs, including cellular and viral genes as well as an ortholog of an important immuno-regulatory cellular miRNA. In this review, we will cover the identification and characterization of miRNAs expressed in the herpesvirus family and discuss the potential significance of their role in viral infection.

PMID:
18087721
PMCID:
PMC3670153
DOI:
10.1007/s00430-007-0070-1
[Indexed for MEDLINE]
Free PMC Article

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