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Antimicrob Agents Chemother. 2008 Mar;52(3):1162-6. Epub 2007 Dec 17.

Antimycobacterial Activity and Mechanism of Action of NAS-91.

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1
Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS, UMR 5235, case 107, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France.

Abstract

The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.

PMID:
18086849
PMCID:
PMC2258518
DOI:
10.1128/AAC.00968-07
[Indexed for MEDLINE]
Free PMC Article
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