The clinical impact and incidence of periocular pigmentation associated with either latanoprost or bimatoprost therapy

Curr Eye Res. 2007 Dec;32(12):1037-43. doi: 10.1080/02713680701750625.

Abstract

Purpose: To evaluate the incidence and characteristics of periocular pigmentation with latanoprost versus bimatoprost.

Methods: A retrospective, active-controlled comparison of consecutive patients treated with latanoprost or bimatoprost for 12 months evaluating patients to determine the incidence, characteristics, and reversibility of periocular pigmentation.

Results: Periocular pigmentation was found in 1% patients treated with latanoprost and 6% patients treated with bimatoprost within 12 months of beginning treatment (p = 0.004).

Conclusions: This study suggests that periocular pigmentation may develop after treatment with latanoprost or bimatoprost.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amides / adverse effects*
  • Antihypertensive Agents / adverse effects*
  • Bimatoprost
  • Cloprostenol / adverse effects
  • Cloprostenol / analogs & derivatives*
  • Eye Color / drug effects
  • Eyelid Diseases / chemically induced*
  • Eyelid Diseases / physiopathology
  • Female
  • Glaucoma, Open-Angle / drug therapy
  • Humans
  • Incidence
  • Intraocular Pressure / drug effects
  • Latanoprost
  • Lipids / adverse effects*
  • Male
  • Middle Aged
  • Ocular Hypertension / drug therapy
  • Pigmentation Disorders / chemically induced*
  • Pigmentation Disorders / physiopathology
  • Prostaglandins F, Synthetic / adverse effects*
  • Retrospective Studies
  • Skin Pigmentation / drug effects*
  • Tonometry, Ocular

Substances

  • Amides
  • Antihypertensive Agents
  • Lipids
  • Prostaglandins F, Synthetic
  • Cloprostenol
  • Latanoprost
  • Bimatoprost