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Adv Exp Med Biol. 2008;605:301-5.

A computer model of mammalian central CO2 chemoreception.

Author information

1
Dartmouth Medical School, Department of Physiology, USA. mykyta.chernov@dartmouth.edu

Abstract

We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.

PMID:
18085289
DOI:
10.1007/978-0-387-73693-8_52
[Indexed for MEDLINE]

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