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Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16.

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.

Author information

1
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA.

Abstract

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

PMID:
18084304
PMCID:
PMC2864125
DOI:
10.1038/nsmb1347
[Indexed for MEDLINE]
Free PMC Article

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