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Nat Methods. 2008 Jan;5(1):57-9. Epub 2007 Dec 16.

Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.

Author information

1
Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA. tk.sinha@vanderbilt.edu

Abstract

We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.

PMID:
18084298
PMCID:
PMC2649801
DOI:
10.1038/nmeth1147
[Indexed for MEDLINE]
Free PMC Article

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