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Nat Genet. 2008 Jan;40(1):26-8. Epub 2007 Dec 16.

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

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1
Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK.

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).

PMID:
18084292
DOI:
10.1038/ng.2007.41
[Indexed for MEDLINE]
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