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Bioorg Med Chem Lett. 2008 Feb 1;18(3):1199-206. Epub 2007 Dec 7.

Discovery of a novel class of selective human CB1 inverse agonists.

Author information

1
Vernalis (R&D) Ltd, Granta Park, Abington, Cambridge CB21 6GB, UK. n.foloppe@vernalis.com

Abstract

Ligand-based virtual screening led to the discovery of a new class of potent inverse agonists of the human cannabinoid receptor 1, hCB(1), which are selective versus hCB(2). These CB(1) ligands present intriguing departures from a classical CB(1) antagonist pharmacophore. Elements of SAR are discussed in this context.

PMID:
18083560
DOI:
10.1016/j.bmcl.2007.11.133
[Indexed for MEDLINE]

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