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Bioorg Med Chem Lett. 2008 Feb 1;18(3):1131-4. Epub 2007 Dec 5.

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.

Author information

1
Gilead Sciences, Department of Medicinal Chemistry, 333 Lakeside Drive, Foster City, CA 94404, USA. tkirschberg@gilead.com

Abstract

A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.

PMID:
18083512
DOI:
10.1016/j.bmcl.2007.11.127
[Indexed for MEDLINE]

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