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Mol Cell. 2007 Dec 14;28(5):739-45.

The DNA damage response: ten years after.

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Department of Pathology, Harvard Medical School, and Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, MA 02115, USA.


The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of DNA damage and resolution of DNA replication problems, coordinating these processes with ongoing cellular physiology. In the past decade, we have witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage. These findings have important implications for aging and cancer.

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