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Mol Cell. 2007 Dec 14;28(5):708-14.

Gene regulation in the postgenomic era: technology takes the wheel.

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Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.


Transcriptional regulation in eukaryotes is a complicated set of processes involving hundreds of proteins. The past decade has seen significant progress in the development of technologies that allow the dissection of the interplay between these regulatory factors. These methodologies have advanced the field to the point where regulation can be examined at the genome level and where intricate regulatory questions can be addressed in multicellular organisms. The application of these technologies over the coming decade promises exciting views of how complexes integrate to create defined regulatory networks.

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