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Int J Gynaecol Obstet. 2008 May;101(2):125-8. Epub 2007 Dec 20.

Prenatal antibiotic treatment does not decrease group B streptococcus colonization at delivery.

Author information

1
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL, USA. lbaecher@hotmail.com

Abstract

OBJECTIVE:

To evaluate whether an outpatient antibiotic regimen decreased group B streptococcal (GBS) colonization to preclude the use of intrapartum antibiotics.

METHODS:

A double-blind randomized controlled trial evaluating prenatal oral amoxicillin versus placebo with the primary outcome of GBS colonization at the time of labor.

RESULTS:

Of those patients receiving both amoxicillin and a repeat culture at the time of labor, 6 of the 14 (43%) tested positive for GBS colonization. Given persistent GBS colonization of 67% (10/15) in the placebo group, treatment with amoxicillin did not significantly impact colonization at the time of delivery (P=0.20).

CONCLUSION:

A regimen of outpatient amoxicillin was associated with persistent GBS colonization in 43% of women at the time of labor. Oral prenatal antibiotic prophylaxis against GBS does not sufficiently reduce colonization to preclude intrapartum intravenous antibiotics.

PMID:
18082163
DOI:
10.1016/j.ijgo.2007.10.012
[Indexed for MEDLINE]

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