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Headache. 2008 Nov-Dec;48(10):1460-7. Epub 2007 Dec 11.

Phenotypic and genetic analysis of a large family with migraine-associated vertigo.

Author information

1
Department of Human Genetics, University of California, Los Angeles, CA 90095, USA.

Abstract

OBJECTIVES:

To describe a large multigenerational family with migraine-associated vertigo (MAV) combining a detailed phenotypic and genetic analysis.

BACKGROUND:

Migraine-associated vertigo is said to be highly prevalent in the general population and, like other migraine syndromes, its etiology is felt to have a strong genetic component. However, so far, there have been no reports of large families with MAV.

METHODS:

Detailed clinical study was conducted on a large multigenerational family with MAV. Genetic study using identical-by-descent analysis with dense single nucleotide polymorphism (SNP) arrays was performed to examine consistent inheritance pattern among the affecteds.

RESULTS:

Clinical features of MAV were variable although most had other migraine symptoms with at least some of their attacks. We did not find a region of the genome shared by all eight subjects with MAV indicating a polygenetic inheritance for MAV even in this single large family.

CONCLUSIONS:

A region on 11q shared by most affected females may contain a susceptibility allele for MAV that is expressed exclusively or predominantly by women.

PMID:
18081823
PMCID:
PMC2846425
DOI:
10.1111/j.1526-4610.2007.01002.x
[Indexed for MEDLINE]
Free PMC Article
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