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Aliment Pharmacol Ther. 2008 Mar 1;27(5):412-21. Epub 2007 Dec 10.

Adipokines and cytokines in non-alcoholic fatty liver disease.

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1
Translational Research Institute, Inova Health System, Fairfax, VA, USA.

Abstract

BACKGROUND:

Several adipocytokines have been implicated in the pathogenesis non-alcoholic fatty liver disease (NAFLD).

AIM:

To assess adipocytokines in NAFLD patients and controls.

METHODS:

A total of 95 patients (26 non-alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non-obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and IL-6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations.

RESULTS:

Serum TNF-alpha and IL-8 were higher in NAFLD patients when compared with both obese and non-obese controls. Analysis involving all patients revealed a significant correlation between serum TNF-alpha and IL-8 (P < 6.319e-08), and between IL-6 and IL-8 (P < 5.271e-15). Homeostatic model assessment scores negatively correlated with adiponectin in NAFLD (P < 0.0032). Serum visfatin was higher in all three obese groups than in non-obese controls (P < 0.02, P < 0.002 and P < 0.008). Visfatin in NASH patients was lower than SS and obese controls. Although TNF-alpha was associated with NAFLD (P < 0.02), it was interdependent on visfatin. In comparison to SS, four factors were independently associated with NASH: age, alanine aminotransferase, IL-8 and adiponectin (P < 0.05). Multivariate analysis indicated that TNF-alpha was the only independent predictor of fibrosis in NASH (P < 0.0004).

CONCLUSION:

These findings support a complex interaction between adipocytokines and the pathogenesis of NAFLD.

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